Dynamic and Thermodynamic Properties of Crystalline Glycine Polymorphs from Multi-Temperature X-ray Diffraction Data

Introduction Glycine having three polymorphs (α, β and γ) at ambient conditions differs in the arrangement of zwitterions in the hydrogen-bonding network and the physical and chemical properties. For insight into the differences in the relative thermodynamic stability of the glycine polymorphs, we apply a novel method of concurrent analysis of multi-temperature atomic displacement parameters (ADPs) [1] to investigate the dynamics of molecules in the crystal and the thermodynamic properties.